Constriction of the fetal ductus arteriosus induced by oxygen, acteylcholine, and norepinephrine in normal dogs and those genetically predisposed to persistent patency.

@article{Knight1973ConstrictionOT,
  title={Constriction of the fetal ductus arteriosus induced by oxygen, acteylcholine, and norepinephrine in normal dogs and those genetically predisposed to persistent patency.},
  author={David H. Knight and Donald F. Patterson and Julius Melbin},
  journal={Circulation},
  year={1973},
  volume={47 1},
  pages={127-32}
}
Functional closure of the isolated perfused ductus arteriosus was studied in normal dog fetuses and in fetuses receiving various known proportions of their genes from dogs with patent ductus arteriosus (PDA). Constriction of the ductus in response to 2, acetylcholine (ACh), and norepinephrine (NE) was evaluated by plotting changes in input conductance against time. Ductuses from the control (normal dog) fetuses constricted in response to high PO2, ACh, and NE, indicating that in the dog the… CONTINUE READING
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