Constraints in antigen presentation severely restrict T cell recognition of the allogeneic fetus.

@article{Erlebacher2007ConstraintsIA,
  title={Constraints in antigen presentation severely restrict T cell recognition of the allogeneic fetus.},
  author={Adrian Erlebacher and Daniela Vencato and Kelly A Price and Dorothy Zhang and L. H. Glimcher},
  journal={The Journal of clinical investigation},
  year={2007},
  volume={117 5},
  pages={1399-411}
}
How the fetus escapes rejection by the maternal immune system remains one of the major unsolved questions in transplantation immunology. Using a system to visualize both CD4+ and CD8+ T cell responses during pregnancy in mice, we find that maternal T cells become aware of the fetal allograft exclusively through "indirect" antigen presentation, meaning that T cell engagement requires the uptake and processing of fetal/placental antigen by maternal APCs. This reliance on a relatively minor… CONTINUE READING
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