Constrained vertebrate evolution by pleiotropic genes

  title={Constrained vertebrate evolution by pleiotropic genes},
  author={Haiyang Hu and Masahiro Uesaka and Song Xue Guo and Kotaro Shimai and Tsai-Ming Lu and Fang Li and Satoko Fujimoto and Masato Ishikawa and Shiping Liu and Yohei Sasagawa and Guojie Zhang and Shigeru Kuratani and Jr-Kai Yu and Takehiro G Kusakabe and Philipp Khaitovich and Naoki Irie},
  journal={Nature Ecology & Evolution},
Despite morphological diversification of chordates over 550 million years of evolution, their shared basic anatomical pattern (or ‘bodyplan’) remains conserved by unknown mechanisms. The developmental hourglass model attributes this to phylum-wide conserved, constrained organogenesis stages that pattern the bodyplan (the phylotype hypothesis); however, there has been no quantitative testing of this idea with a phylum-wide comparison of species. Here, based on data from early-to-late embryonic… CONTINUE READING
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Functional roles of Aves class-specific cis-regulatory elements on macroevolution of bird-specific features

  • R Seki
  • Nat. Commun
  • 2017

High expression of new genes in trochophore enlightening the ontogeny and evolution of trochozoans

  • F Xu
  • Sci. Rep
  • 2016

Constraints evolve: context dependency of gene effects allows evolution of pleiotropy

  • M. Pavlicev, J. M. Cheverud
  • Annu. Rev. Ecol. Evol. Syst
  • 2015

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