Constrained Deep Weak Supervision for Histopathology Image Segmentation
@article{Jia2017ConstrainedDW, title={Constrained Deep Weak Supervision for Histopathology Image Segmentation}, author={Zhipeng Jia and Xingyi Huang and Eric I-Chao Chang and Yan Xu}, journal={IEEE Transactions on Medical Imaging}, year={2017}, volume={36}, pages={2376-2388} }
In this paper, we develop a new weakly supervised learning algorithm to learn to segment cancerous regions in histopathology images. [] Key Method The contributions of our algorithm are threefold: 1) we build an end-to-end learning system that segments cancerous regions with fully convolutional networks (FCNs) in which image-to-image weakly-supervised learning is performed; 2) we develop a DWS formulation to exploit multi-scale learning under weak supervision within FCNs; and 3) constraints about positive…
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52 References
Weakly supervised histopathology cancer image segmentation and classification
- Computer ScienceMedical Image Anal.
- 2014
Contexts-Constrained Multiple Instance Learning for Histopathology Image Analysis
- Computer Science
- 2012
A new algorithm along the line of weakly supervised learning is proposed; context constraints as a prior for multiple instance learning (ccMIL) is introduced, which significantly reduces the ambiguity in weak supervision (a 20% gain).
Constrained Convolutional Neural Networks for Weakly Supervised Segmentation
- Computer Science2015 IEEE International Conference on Computer Vision (ICCV)
- 2015
This work proposes Constrained CNN (CCNN), a method which uses a novel loss function to optimize for any set of linear constraints on the output space of a CNN, and demonstrates the generality of this new learning framework.
Weakly Supervised Cascaded Convolutional Networks
- Computer Science2017 IEEE Conference on Computer Vision and Pattern Recognition (CVPR)
- 2017
This work introduces two new architecture of cascaded networks, with either two cascade stages or three which are trained in an end-to-end pipeline to learn a convolutional neural network (CNN) under such conditions.
DCAN: Deep Contour-Aware Networks for Accurate Gland Segmentation
- Computer Science2016 IEEE Conference on Computer Vision and Pattern Recognition (CVPR)
- 2016
An efficient deep contour-aware network (DCAN) to solve this challenging problem under a unified multi-task learning framework and can be efficient when applied to large-scale histopathological data without resorting to additional steps to generate contours based on low-level cues for post-separating.
Weakly-and Semi-Supervised Learning of a Deep Convolutional Network for Semantic Image Segmentation
- Computer Science2015 IEEE International Conference on Computer Vision (ICCV)
- 2015
Expectation-Maximization (EM) methods for semantic image segmentation model training under weakly supervised and semi-supervised settings are developed and extensive experimental evaluation shows that the proposed techniques can learn models delivering competitive results on the challenging PASCAL VOC 2012 image segmentsation benchmark, while requiring significantly less annotation effort.
Deep convolutional activation features for large scale Brain Tumor histopathology image classification and segmentation
- Computer Science2015 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP)
- 2015
We propose a simple, efficient and effective method using deep convolutional activation features (CNNs) to achieve stat- of-the-art classification and segmentation for the MICCAI 2014 Brain Tumor…
U-Net: Convolutional Networks for Biomedical Image Segmentation
- Computer ScienceMICCAI
- 2015
It is shown that such a network can be trained end-to-end from very few images and outperforms the prior best method (a sliding-window convolutional network) on the ISBI challenge for segmentation of neuronal structures in electron microscopic stacks.
Deeply-Supervised Nets
- Computer ScienceAISTATS
- 2015
The proposed deeply-supervised nets (DSN) method simultaneously minimizes classification error while making the learning process of hidden layers direct and transparent, and extends techniques from stochastic gradient methods to analyze the algorithm.
Fully Convolutional Multi-Class Multiple Instance Learning
- Computer ScienceICLR
- 2015
This work proposes a novel MIL formulation of multi-class semantic segmentation learning by a fully convolutional network that exploits the further supervision given by images with multiple labels.