Constitutively active transforming growth factor β receptor 1 in the mouse ovary promotes tumorigenesis

Abstract

Despite the well-established tumor suppressive role of TGFβ proteins, depletion of key TGFβ signaling components in the mouse ovary does not induce a growth advantage. To define the role of TGFβ signaling in ovarian tumorigenesis, we created a mouse model expressing a constitutively active TGFβ receptor 1 (TGFBR1) in ovarian somatic cells using conditional… (More)
DOI: 10.18632/oncotarget.10149

Topics

Cite this paper

@inproceedings{Gao2016ConstitutivelyAT, title={Constitutively active transforming growth factor β receptor 1 in the mouse ovary promotes tumorigenesis}, author={Yang Gao and David F Vincent and Anna Jane Davis and Owen J. Sansom and Laurent Bartholin and Qinglei Li}, booktitle={Oncotarget}, year={2016} }