Constitutively active thyrotropin and thyrotropin-releasing hormone receptors and their inverse agonists.

Abstract

Receptors for thyrotropin-releasing hormone (TRH) and thyrotropin (thyroid-stimulating hormone-TSH) are important regulators of the function of the TSH-producing cells of the anterior pituitary gland and the thyroid gland, respectively, and thereby play a central role in thyroid hormone homeostasis. Although the roles of TRH- and TSH-stimulated signaling in… (More)
DOI: 10.1016/B978-0-12-381296-4.00009-9

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