Constitutively active retinoid receptors exhibit interfamily and intrafamily promoter specificity.

@article{Underhill1994ConstitutivelyAR,
  title={Constitutively active retinoid receptors exhibit interfamily and intrafamily promoter specificity.},
  author={T. Michael Underhill and David E. Cash and Elwood Linney},
  journal={Molecular endocrinology},
  year={1994},
  volume={8 3},
  pages={274-85}
}
Retinoid receptors are ligand activated transcription factors that regulate gene transcription through a complex network of interactions with members of the nuclear hormone receptor superfamily. Although ligand is required for trans-activation, addition of ligand to mammalian cells in vitro complicates the study of individual activated retinoid receptors. In order to circumvent this problem we have constructed a series of retinoid receptors which do not require ligand for trans-activation. This… CONTINUE READING