Constitutively active protein phosphatase 1α causes Rb-dependent G1 arrest in human cancer cells

  title={Constitutively active protein phosphatase 1α causes Rb-dependent G1 arrest in human cancer cells},
  author={Norbert Berndt and Mariam M. Dohadwala and Cathy W.Y. Liu},
  journal={Current Biology},
BACKGROUND The retinoblastoma protein (Rb) needs to be phosphorylated by cyclin-dependent kinases (CDKs) before mammalian cells can enter the S phase of the cell cycle. As protein phosphatase 1 (PP1) activates Rb and is itself a target for inhibitory phosphorylation by CDKs in vitro, we asked whether any effects of PP1 on cell cycle progression depend on its phosphorylation and are mediated through Rb. RESULTS Using electrotransfer of recombinant protein into Rb-positive and Rb-negative cells… CONTINUE READING
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