Constitutively active phosphatase inhibitor-1 improves cardiac contractility in young mice but is deleterious after catecholaminergic stress and with aging.

@article{Wittkpper2010ConstitutivelyAP,
  title={Constitutively active phosphatase inhibitor-1 improves cardiac contractility in young mice but is deleterious after catecholaminergic stress and with aging.},
  author={Katrin Wittk{\"o}pper and Larissa Fabritz and Stefan Neef and Katharina R Ort and Clemens Grefe and Bernhard W. Uns{\"o}ld and Paulus Kirchhof and Lars Siegfried Maier and Gerd Hasenfuss and Dobromir Dobrev and Thomas Eschenhagen and Ali El-Armouche},
  journal={The Journal of clinical investigation},
  year={2010},
  volume={120 2},
  pages={617-26}
}
Phosphatase inhibitor-1 (I-1) is a distal amplifier element of beta-adrenergic signaling that functions by preventing dephosphorylation of downstream targets. I-1 is downregulated in human failing hearts, while overexpression of a constitutively active mutant form (I-1c) reverses contractile dysfunction in mouse failing hearts, suggesting that I-1c may be a candidate for gene therapy. We generated mice with conditional cardiomyocyte-restricted expression of I-1c (referred to herein as dTGI-1c… CONTINUE READING

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