Constitutively active mitogen-activated protein kinase kinase MEK1 disrupts morphogenesis and induces an invasive phenotype in Madin-Darby canine kidney epithelial cells.

@article{Montesano1999ConstitutivelyAM,
  title={Constitutively active mitogen-activated protein kinase kinase MEK1 disrupts morphogenesis and induces an invasive phenotype in Madin-Darby canine kidney epithelial cells.},
  author={Roberto Montesano and Jesus V. Soriano and Ghamartaj Hosseini and Michael Sean Pepper and Herbert Schramek},
  journal={Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research},
  year={1999},
  volume={10 5},
  pages={317-32}
}
During certain developmental processes, as well as during tumor progression, polarized epithelial cells integrated within multicellular structures convert into scattered, freely migrating fibroblast-like cells. Despite the biological and clinical importance of this phenomenon, the intracellular biochemical cascades that control the switch between the epithelial and mesenchymal phenotypes have not been elucidated. Using Madin-Darby canine kidney (MDCK) cells (clone C7) as a model system, we have… CONTINUE READING
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