Constitutively active calcineurin in skeletal muscle increases endurance performance and mitochondrial respiratory capacity.

@article{Jiang2010ConstitutivelyAC,
  title={Constitutively active calcineurin in skeletal muscle increases endurance performance and mitochondrial respiratory capacity.},
  author={Lake Qunfeng Jiang and Pablo Miguel Garc{\'i}a-Rov{\'e}s and Tha{\'i}s de Castro Barbosa and Juleen R Zierath},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2010},
  volume={298 1},
  pages={E8-E16}
}
Expression of an activated form of calcineurin in skeletal muscle selectively up-regulates slow-fiber-specific gene expression. Here, we tested the hypothesis that expression of activated calcineurin in skeletal muscle influences body composition, energy homeostasis, and exercise performance. Using transgenic mice expressing activated calcineurin (CnA*) in skeletal muscle (MCK-CnA* transgenic mice), we determined whether skeletal muscle reprogramming by calcineurin activation affects exercise… CONTINUE READING
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