Constitutively active adenylyl cyclase mutant requires neither G proteins nor cytosolic regulators.

@article{Parent1996ConstitutivelyAA,
  title={Constitutively active adenylyl cyclase mutant requires neither G proteins nor cytosolic regulators.},
  author={Carole A Parent and Peter N. Devreotes},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 31},
  pages={18333-6}
}
Receptor-mediated G protein-linked adenylyl cyclase systems are universal signal transducers. We exploited the essential role of this cascade in Dictyostelium development to screen for random mutations in the catalytic component, ACA. This enzyme is activated by G protein betagamma-subunits acting in concert with a novel cytosolic regulator, CRAC. By suppression of the CRAC-null phenotype, we isolated constitutively active versions of the enzyme that require neither exogenous stimuli nor… CONTINUE READING
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Constitutively Active Adenylyl Cyclase Mutant

  • Z S., D. Hahn, Z. H. Huang, W. J. Tang
  • J. Biol. Chem
  • 1995

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