Constitutively active SHP2 cooperates with HoxA10 overexpression to induce acute myeloid leukemia.

@article{Wang2009ConstitutivelyAS,
  title={Constitutively active SHP2 cooperates with HoxA10 overexpression to induce acute myeloid leukemia.},
  author={Hao Wang and Stephan Lindsey and Iwona Konieczna and Ling Bei and Elizabeth A. Horvath and Weiqi Huang and Gurveen Saberwal and Elizabeth A. Eklund},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 4},
  pages={2549-67}
}
The homeodomain transcription factor HoxA10 is maximally expressed in myeloid progenitor cells. Sustained HoxA10 expression during differentiation has been described in poor prognosis human acute myeloid leukemia (AML). Consistent with this, engineered overexpression of HoxA10 in murine bone marrow induces a myeloproliferative disorder that progresses to… CONTINUE READING