Constitutively active PDX1 induced efficient insulin production in adult murine liver.

  title={Constitutively active PDX1 induced efficient insulin production in adult murine liver.},
  author={Junta Imai and Hideki Katagiri and Tetsuya Yamada and Yasushi Ishigaki and Takehide Ogihara and Kenji Uno and Yutaka Hasegawa and Junhong Gao and Hisamitsu Ishihara and Hironobu Sasano and Hiroyuki Mizuguchi and Tomoichiro Asano and Yoshitomo Oka},
  journal={Biochemical and biophysical research communications},
  volume={326 2},
To generate insulin-producing cells in the liver, recombinant adenovirus containing a constitutively active mutant of PDX1 (PDX1-VP16), designed to activate target genes without the need for protein partners, was prepared and administered intravenously to streptozotocin (STZ)-treated diabetic mice. The effects were compared with those of administering wild-type PDX1 (wt-PDX1) adenovirus. Administration of these adenoviruses at 2x10(8)pfu induced similar levels of PDX1 protein expression in the… CONTINUE READING

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