Constitutively active MEK1 is sufficient to induce epithelial-to-mesenchymal transition in intestinal epithelial cells and to promote tumor invasion and metastasis.

@article{Lemieux2009ConstitutivelyAM,
  title={Constitutively active MEK1 is sufficient to induce epithelial-to-mesenchymal transition in intestinal epithelial cells and to promote tumor invasion and metastasis.},
  author={Etienne Lemieux and S{\'e}bastien J Bergeron and V{\'e}ronique Durand and Claude Asselin and Caroline Saucier and Nathalie Rivard},
  journal={International journal of cancer},
  year={2009},
  volume={125 7},
  pages={
          1575-86
        }
}
Constitutive activation of the MAP kinase kinase MEK1 induces oncogenic transformation in intestinal epithelial cells. Loss of cell-cell adhesion followed by the dissociation of epithelial structures is a prerequisite for increased cell motility and tumor invasion. This phenotypic switch is designated epithelial-to-mesenchymal transition (EMT). EMT also plays an important role in determining the dissemination of tumors. However, the role of MEK1 in intestinal EMT, tumor invasion and metastasis… CONTINUE READING

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