Constitutively active HIF-1alpha improves perfusion and arterial remodeling in an endovascular model of limb ischemia.

@article{Patel2005ConstitutivelyAH,
  title={Constitutively active HIF-1alpha improves perfusion and arterial remodeling in an endovascular model of limb ischemia.},
  author={Tarak H. Patel and Hideo Kimura and Clifford R. Weiss and Gregg L Semenza and Lawrence Vincent Hofmann},
  journal={Cardiovascular research},
  year={2005},
  volume={68 1},
  pages={144-54}
}
OBJECTIVE Hypoxia-inducible factor 1 (HIF-1) regulates the expression of angiogenic growth factors. We analyzed the effect of intramuscular (i.m.) delivery of AdCA5, an adenovirus encoding a constitutively active form of the HIF-1alpha subunit, in a novel model of limb ischemia. METHODS AdCa5 or AdLacZ (6 x 10(8) pfu) was injected into male New Zealand… CONTINUE READING