Constitutively active BMP type I receptors transduce BMP-2 signals without the ligand in C2C12 myoblasts.

@article{Akiyama1997ConstitutivelyAB,
  title={Constitutively active BMP type I receptors transduce BMP-2 signals without the ligand in C2C12 myoblasts.},
  author={Shinichiro Akiyama and Takenobu Katagiri and Mikio Namiki and Noboru Yamaji and Naoki Yamamoto and Katsuyoshi Miyama and Hitoshi Shibuya and Naoto Ueno and John M. Wozney and Toshio Suda},
  journal={Experimental cell research},
  year={1997},
  volume={235 2},
  pages={362-9}
}
Bone morphogenetic protein-2 (BMP-2), a member of transforming growth factor-beta superfamily, inhibits the terminal differentiation of C2C12 myoblasts and changes their differentiation pathway into cells expressing osteoblast phenotypes such as alkaline phosphatase (ALP) activity and osteocalcin production (Katagiri et al., 1994, J. Cell Biol. 127, 1755-1766). Two type I receptors for BMP-2 (BMPR-IA and BMPR-IB) have been cloned, but the role of the respective receptors in signal transduction… CONTINUE READING

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