Constitutively active AKT depletes hematopoietic stem cells and induces leukemia in mice.

@article{Krivtsov2010ConstitutivelyAA,
  title={Constitutively active AKT depletes hematopoietic stem cells and induces leukemia in mice.},
  author={Andrei V Krivtsov and Rachel O. Okabe and Jared Jason Ganis and Maricel Gozo and Tulasi Khandan and Mahnaz Paktinat and Dwight Gary Gilliland and Kira Gritsman},
  journal={Blood},
  year={2010},
  volume={115 7},
  pages={
          1406-15
        }
}
Human cancers, including acute myeloid leukemia (AML), commonly display constitutive phosphoinositide 3-kinase (PI3K) AKT signaling. However, the exact role of AKT activation in leukemia and its effects on hematopoietic stem cells (HSCs) are poorly understood. Several members of the PI3K pathway, phosphatase and tensin homolog (Pten), the forkhead box, subgroup O (FOXO) transcription factors, and TSC1, have demonstrated functions in normal and leukemic stem cells but are rarely mutated in… CONTINUE READING

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 128 CITATIONS, ESTIMATED 65% COVERAGE

FILTER CITATIONS BY YEAR

2010
2019

CITATION STATISTICS

  • 17 Highly Influenced Citations

  • Averaged 11 Citations per year from 2017 through 2019

References

Publications referenced by this paper.
SHOWING 1-10 OF 32 REFERENCES

Chronic lymphocytic leukaemia and acute myeloid leukaemia are not associated with AKT1 pleckstrin homology domain (E17K) mutations

T Zenz, K Dohner, +3 authors L. Bullinger
  • Br J Haematol
  • 2008

Mutations in the catalytic subunit of class IA PI3K confer leukemogenic potential to hematopoietic cells

S Horn, U Bergholz, M Jucker
  • On - cogene
  • 2008