Constitutively Activated NLRP3 Inflammasome Causes Inflammation and Abnormal Skeletal Development in Mice

@inproceedings{Bonar2012ConstitutivelyAN,
  title={Constitutively Activated NLRP3 Inflammasome Causes Inflammation and Abnormal Skeletal Development in Mice},
  author={Sheri L. Bonar and Susannah D. Brydges and Christophe Pietras and Matthew D. McGeough and C. A. Rodr'iguez Pena and Debbie Chen and Susan K. Grimston and Cynthia L. Hickman-Brecks and Soumya Ravindran and A Mcalinden and Deborah V Novack and Daniel L. Kastner and Roberto Civitelli and Hal M Hoffman and Gabriel Mbalaviele},
  booktitle={PloS one},
  year={2012}
}
The NLRP3 inflammasome complex is responsible for maturation of the pro-inflammatory cytokine, IL-1β. Mutations in NLRP3 are responsible for the cryopyrinopathies, a spectrum of conditions including neonatal-onset multisystem inflammatory disease (NOMID). While excessive production of IL-1β and systemic inflammation are common to all cryopyrinopathy disorders, skeletal abnormalities, prominently in the knees, and low bone mass are unique features of patients with NOMID. To gain insights into… CONTINUE READING

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