Constitutive upregulation of chaperone-mediated autophagy in Huntington's disease.

  title={Constitutive upregulation of chaperone-mediated autophagy in Huntington's disease.},
  author={Hiroshi Koga and Marta Mart{\'i}nez-Vicente and Esperanza Arias and Susmita Kaushik and David Sulzer and Ana Mar{\'i}a Cuervo},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={31 50},
Autophagy contributes to the removal of prone-to-aggregate proteins, but in several instances these pathogenic proteins have been shown to interfere with autophagic activity. In the case of Huntington's disease (HD), a congenital neurodegenerative disorder resulting from mutation in the huntingtin protein, we have previously described that the mutant protein interferes with the ability of autophagic vacuoles to recognize cytosolic cargo. Growing evidence supports the existence of cross talk… CONTINUE READING
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