Constitutive transduction of peptide transporter and HLA genes restores antigen processing function and cytotoxic T cell-mediated immune recognition of human melanoma cells.

@article{White1998ConstitutiveTO,
  title={Constitutive transduction of peptide transporter and HLA genes restores antigen processing function and cytotoxic T cell-mediated immune recognition of human melanoma cells.},
  author={Christine A. White and Scott A. Thomson and Lucienne Cooper and Peter van Endert and Robert Tamp{\'e} and Barbara E. H. Coupar and Lu Gui Qiu and Peter G Parsons and Denis J. Moss and Rajiv Khanna},
  journal={International journal of cancer},
  year={1998},
  volume={75 4},
  pages={590-5}
}
Potentiation of immunogenicity of malignant cells by gene transduction provides a unique opportunity for immune targeting of human cancers in vivo. This approach is undoubtedly influenced by the ability of the malignant cells to process and present endogenously target epitopes on their cell surface for immune recognition by cytotoxic T lymphocytes (CTLs). In the present study, we have investigated potential immune-resistance pathways in human malignant melanoma by analyzing the major… CONTINUE READING
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