Constitutive secretion of tau protein by an unconventional mechanism

  title={Constitutive secretion of tau protein by an unconventional mechanism},
  author={Xiyun Chai and Jeffrey L. Dage and Martin Citron},
  journal={Neurobiology of Disease},
The microtubule-associated protein tau plays a critical role in the pathogenesis of Alzheimer's disease and several related disorders. In the disease tau aggregates into paired helical and straight filaments, which can form higher order neurofibrillary tangles in neurons and this pathology is associated with progressive neuronal loss and cognitive decline. Tau is a cytoplasmic protein and is thought to be released only from degenerating cells. In contrast, here we provide evidence that tau is… CONTINUE READING


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Publications referenced by this paper.
Showing 1-10 of 49 references

Exosomes: endosomal-derived vesicles shipping extracellular messages.

Current opinion in cell biology • 2004
View 3 Excerpts
Highly Influenced

Human-based systems for in vitro modeling: the development and characterization of induced pluripotent stem cell (iPSC)-derived neurons for preclinical use

C Cliff
17th Annual Society for Biomolecular Screening Conference and Exhibition, • 2011

In vivomicrodialysis reveals age-dependent decrease of brain interstitialfluid tau levels in P301Shuman tau transgenicmice

K Yamada
J. Neurosci • 2011

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