Constitutive promoter occupancy by the MBF-1 activator and chromatin modification of the developmental regulated sea urchin alpha-H2A histone gene.

@article{Caro2007ConstitutivePO,
  title={Constitutive promoter occupancy by the MBF-1 activator and chromatin modification of the developmental regulated sea urchin alpha-H2A histone gene.},
  author={Valentina Di Caro and Vincenzo Cavalieri and Raffaella Melfi and Giovanni Spinelli},
  journal={Journal of molecular biology},
  year={2007},
  volume={365 5},
  pages={1285-97}
}
The tandemly repeated sea urchin alpha-histone genes are developmentally regulated. These genes are transcribed up to the early blastula stage and permanently silenced as the embryos approach gastrulation. As previously described, expression of the alpha-H2A gene depends on the binding of the MBF-1 activator to the 5' enhancer, while down-regulation relies on the functional interaction between the 3' sns 5 insulator and the GA repeats located upstream of the enhancer. As persistent MBF-1… CONTINUE READING

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