Constitutive production of NF-kappaB2 p52 is not tumorigenic but predisposes mice to inflammatory autoimmune disease by repressing Bim expression.

@article{Wang2008ConstitutivePO,
  title={Constitutive production of NF-kappaB2 p52 is not tumorigenic but predisposes mice to inflammatory autoimmune disease by repressing Bim expression.},
  author={Zhe Wang and Baochun Zhang and Liqun Yang and Jane L. Ding and H T Ding},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 16},
  pages={10698-706}
}
Normal development of the immune system requires regulated processing of NF-kappaB2 p100 to p52, which activates NF-kappaB2 signaling. Constitutive production of p52 has been suggested as a major mechanism underlying lymphomagenesis induced by NF-kappaB2 mutations, which occur recurrently in a variety of human lymphoid malignancies. To test the hypothesis, we generated transgenic mice with targeted expression of p52 in lymphocytes. In contrast to their counterparts expressing the tumor-derived… CONTINUE READING
17 Citations
1 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

References

Publications referenced by this paper.

Signaling in Autoimmunity 10706 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

  • A. Enders, P. Bouillet, H. Puthalakath, Y. Xu, D. M. Tarlinton, A. Strasser
  • J. Exp. Med
  • 2003

Similar Papers

Loading similar papers…