Constitutive p21-activated kinase (PAK) activation in breast cancer cells as a result of mislocalization of PAK to focal adhesions.

@article{Stofega2004ConstitutivePK,
  title={Constitutive p21-activated kinase (PAK) activation in breast cancer cells as a result of mislocalization of PAK to focal adhesions.},
  author={Mary R Stofega and Luraynne C. Sanders and Elisabeth M M Gardiner and Gary M. Bokoch},
  journal={Molecular biology of the cell},
  year={2004},
  volume={15 6},
  pages={
          2965-77
        }
}
Cytoskeletal remodeling is critical for cell adhesion, spreading, and motility. p21-activated kinase (PAK), an effector molecule of the Rho GTPases Rac and Cdc42, has been implicated in cytoskeletal remodeling and cell motility. PAK kinase activity and subcellular distribution are tightly regulated by rapid and transient localized Rac and Cdc42 activation, and by interactions mediated by adapter proteins. Here, we show that endogenous PAK is constitutively activated in certain breast cancer… CONTINUE READING
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