Constitutive overexpression of cyclin D1 but not cyclin E confers acute resistance to antiestrogens in T-47D breast cancer cells.

@article{Hui2002ConstitutiveOO,
  title={Constitutive overexpression of cyclin D1 but not cyclin E confers acute resistance to antiestrogens in T-47D breast cancer cells.},
  author={Rina Hui and Georgina L Finney and Jason S. Carroll and Christine S. L. Lee and Elizabeth A. Musgrove and Robert Lyndsay Sutherland},
  journal={Cancer research},
  year={2002},
  volume={62 23},
  pages={
          6916-23
        }
}
Cyclin D1 and cyclin E are overexpressed in approximately 45% and 30% of breast cancers, respectively, and adverse associations with patient outcome have been reported. The potential roles of cyclin D1 and cyclin E expression as markers of therapeutic responsiveness to the pure steroidal antiestrogen ICI 182780 were investigated using T-47D breast cancer cell lines constitutively overexpressing cyclin D1 or cyclin E. Measurement of S phase fraction, phosphorylation states of the retinoblastoma… CONTINUE READING
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Ectopic expression of cyclin E in estrogen responsive cells abrogates antiestrogen mediated growth arrest

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  • Oncogene
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