Constitutive overexpression of Norrin activates Wnt/β-catenin and endothelin-2 signaling to protect photoreceptors from light damage

@article{Braunger2013ConstitutiveOO,
  title={Constitutive overexpression of Norrin activates Wnt/β-catenin and endothelin-2 signaling to protect photoreceptors from light damage},
  author={Barbara M. Braunger and Andreas Ohlmann and Marcus Koch and Naoyuki Tanimoto and Ernst R Tamm},
  journal={Neurobiology of Disease},
  year={2013},
  volume={50},
  pages={1-12}
}
Norrin is a retinal signaling molecule which is expressed in Müller glia and binds to Frizzled-4 to activate canonical Wnt/β-catenin signaling. Norrin is part of an essential signaling system that controls the formation of retinal capillaries during development. To evaluate neuroprotective properties of Norrin independently from its function during retinal angiogenesis, we generated transgenic mice (Rpe65-Norrin) that constitutively express Norrin in the retinal pigmented epithelium… CONTINUE READING

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