Constitutive nuclear localization of Janus kinases 1 and 2.

  title={Constitutive nuclear localization of Janus kinases 1 and 2.},
  author={Peter E. Lobie and B Ronsin and Olli Silvennoinen and Lars Arne Haldos{\'e}n and Gunnar Norstedt and G{\'e}rard Morel},
  volume={137 9},
Both GH and the GH receptor have been reported to undergo rapid nuclear translocation. Janus kinases (JAK) 1 and 2 have been implicated in GH receptor signaling, and both of these kinases are phosphorylated by GH stimulation. In this report, we have investigated the subcellular distribution of JAK1 and JAK2. Both JAK1 and JAK2 exhibit a nucleocytoplasmic distribution by immunocytochemistry in unstimulated serum deprived CHO cells stably transfected with rat GH receptor complementary DNA (cDNA… CONTINUE READING

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