Constitutive mobilization of CD34+ cells into the peripheral blood in idiopathic myelofibrosis may be due to the action of a number of proteases.

@article{Xu2005ConstitutiveMO,
  title={Constitutive mobilization of CD34+ cells into the peripheral blood in idiopathic myelofibrosis may be due to the action of a number of proteases.},
  author={Mingjiang Xu and Edward Bruno and Joseph Chao and Stephen Huang and Guido Finazzi and Steven M Fruchtman and Uday Popat and Josef T Prchal and Giovanni Barosi and Ronald F. Hoffman},
  journal={Blood},
  year={2005},
  volume={105 11},
  pages={4508-15}
}
Idiopathic myelofibrosis (IM) is characterized by increased numbers of CD34(+) cells in the peripheral blood (PB). We explored the possible mechanisms underlying this abnormal trafficking of CD34(+) cells. Plasma levels of neutrophil elastase (NE), total and active matrix metalloproteinase 9 (MMP-9), and soluble vascular cell adhesion molecule-1 (sVCAM-1) were dramatically increased in IM. The absolute number of CD34(+) cells in the PB was correlated with the levels of sVCAM-1. Marked… CONTINUE READING