Constitutive mTORC1 activation by a herpesvirus Akt surrogate stimulates mRNA translation and viral replication.

@article{Chuluunbaatar2010ConstitutiveMA,
  title={Constitutive mTORC1 activation by a herpesvirus Akt surrogate stimulates mRNA translation and viral replication.},
  author={Uyanga Chuluunbaatar and Richard Roller and Morris E. Feldman and Stuart Z Brown and Kevan M. Shokat and Ian J. Mohr},
  journal={Genes & development},
  year={2010},
  volume={24 23},
  pages={2627-39}
}
All viruses require cellular ribosomes to translate their mRNAs. Viruses producing methyl-7 (m⁷) GTP-capped mRNAs, like Herpes Simplex Virus-1 (HSV-1), stimulate cap-dependent translation by activating mTORC1 to inhibit the translational repressor 4E-binding protein 1 (4E-BP1). Here, we establish that the HSV-1 kinase Us3 masquerades as Akt to activate mTORC1. Remarkably, Us3 displays no sequence homology with the cellular kinase Akt, yet directly phosphorylates tuberous sclerosis complex 2… CONTINUE READING

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