Constitutive interaction of the P2Y2 receptor with the hematopoietic cell-specific G protein G(alpha16) and evidence for receptor oligomers.

@article{Kotevic2005ConstitutiveIO,
  title={Constitutive interaction of the P2Y2 receptor with the hematopoietic cell-specific G protein G(alpha16) and evidence for receptor oligomers.},
  author={Ivana Kotevic and K M Kirschner and Hartmut Porzig and Kurt Baltensperger},
  journal={Cellular signalling},
  year={2005},
  volume={17 7},
  pages={869-80}
}
Hematopoietic cells uniquely express G(alpha16), a G protein alpha-subunit of the G(q)-type. G(alpha16) is obligatory for P2Y2 receptor-dependent Ca2+-mobilization in human erythroleukemia cells and induces hematopoietic cell differentiation. We tested whether P2Y2 receptors physically interact with G(alpha16). Receptor and G protein were fused to cyan (CFP… CONTINUE READING