Constitutive histamine H2 receptor activity regulates serotonin release in the substantia nigra

@article{Threlfell2008ConstitutiveHH,
  title={Constitutive histamine H2 receptor activity regulates serotonin release in the substantia nigra},
  author={Sarah Threlfell and Richard Exley and Stephanie J. Cragg and Susan A. Greenfield},
  journal={Journal of Neurochemistry},
  year={2008},
  volume={107}
}
The substantia nigra pars reticulata (SNr) forms a principal output from the basal ganglia. It also receives significant histamine (HA) input from the tuberomammillary nucleus whose functions in SNr remain poorly understood. One identified role is the regulation of serotonin (5‐HT) neurotransmission via the HA‐H3 receptor. Here we have explored regulation by another HA receptor expressed in SNr, the H2‐receptor (H2R), by monitoring electrically evoked 5‐HT release with fast‐scan cyclic… 
Enhanced central histaminergic transmission attenuates compulsive-like behavior in mice
Histamine modulates spinal motoneurons and locomotor circuits
TLDR
It is demonstrated that histamine induces direct motoneuron membrane depolarization and modulation of locomotor output, indicating new potential targets for locomotor neurorehabilitation.
Histaminergic system in brain disorders: lessons from the translational approach and future perspectives
TLDR
The role of histaminergic system in brain disorders, as well as the effects of different histamine antagonists on animal models and humans, are summarized.
Involvement of histamine receptors in the atypical antipsychotic profile of clozapine: a reassessment in vitro and in vivo
TLDR
Clozapine and its active metabolite NDMC interact with the four human histamine receptors at clinically relevant concentrations, which may substantiate, at least in part, the atypical antipsychotic profile of clozapines, as well as its central and peripheral side effects such as sedation and weight gain.
Molecular Aspects of Histamine Receptors
TLDR
In this chapter the molecular aspects of histamine receptors are described, including expression profile, intracellular signaling, and how histamine receptor activity can be modulated by ligands targeting thehistamine receptor binding sites.
Antihistaminergics and inverse agonism: potential therapeutic applications.
Histamine inhibits the melanin‐concentrating hormone system: implications for sleep and arousal
TLDR
Melanin‐concentrating hormone neurons express histamine‐3 receptor (H3R) mRNA but not histamines‐1 (H1R) or Histamine‐2 (H2R) receptor mRNA, and histamine may function to silence MCH neurons during wakefulness.
WINCS-BASED WIRELESS ELECTROCHEMICAL MONITORING OF SEROTONIN (5-HT) USING FAST-SCAN CYCLIC VOLTAMMETRY: PROOF OF PRINCIPLE
TLDR
WINCS supported high-fidelity wireless serotonin monitoring by FSCV at a CFM, and in brain slices, WINCS reliably detected sub-second serotonin release in the dorsal raphe nucleus evoked by local high-frequency stimulation.
...
...

References

SHOWING 1-10 OF 69 REFERENCES
Histamine H3 Receptors Inhibit Serotonin Release in Substantia Nigra Pars Reticulata
TLDR
The potent regulation of 5-HT by H3Rs reported here not only elucidates HA function in the SNr but also raises the possibility of novel targets for basal ganglia therapies.
Opposite functions of histamine H1 and H2 receptors and H3 receptor in substantia nigra pars reticulata.
TLDR
H1 and H2 receptors and H3 receptor exert opposite effects on SNr inhibitory projection neurons and functional balance of these different histamine receptors may contribute to the proper intensity and pattern of basal ganglia output and, as a consequence, exert important effects on motor control.
Histaminergic neurons modulate acetylcholine release in the ventral striatum: role of H1 and H2 histamine receptors
TLDR
The findings suggest that the release of acetylcholine in the striatum is modulated by neighbouring histaminergic neurons in a complex way and Stimulation of H1 histamine receptors, probably located on cholinergic neurons, enhances acetylCholine release.
Histaminergic neurons modulate acetylcholine release in the ventral striatum: role of H3 histamine receptors
TLDR
The findings show that, in the striatum, the activity of cholinergic neurons is permanently modulated by neighbouring histaminergic nerve terminals and axons, and the release of acetylcholine is also permanently inhibited by neighbouring GABAergic neurons.
Presynaptic histamine H2 receptors modulate the sympathetic nerve transmission in the isolated rat vas deferens; no role for H3-receptors
TLDR
The data suggest that rat vas deferens contains presynaptic histamine H2 receptors, able to mediate inhibitory effects on the sympathetic transmission, while histamines H3 receptors are apparently not involved.
Comparison of Serotonin and Dopamine Release in Substantia Nigra and Ventral Tegmental Area: Region and Species Differences
TLDR
Comparison of electrically evoked, somatodendritic release of dopamine (DA) with axonal release of serotonin (5‐HT) in the substantia nigra and ventral tegmental area in vitro by using fast‐scan cyclic voltammetry with carbon‐fibre microelectrodes shows axonal 5‐HT transmission in midbrain exhibits both species and site selectivity.
Inverse agonism of histamine H2 antagonist accounts for upregulation of spontaneously active histamine H2 receptors.
TLDR
The displayed inverse agonism of H2 antagonists appears to be a mechanistic basis for the observed H2 antagonist-induced H2 receptor upregulation in transfected CHO cells, which shed new light on the pharmacological classification of the H 2 antagonists and may offer a plausible explanation for the observation of tolerance after prolonged clinical use.
Differential Actions of Serotonin, Mediated by 5-HT1Band 5-HT2C Receptors, on GABA-Mediated Synaptic Input to Rat Substantia Nigra Pars Reticulata Neurons In Vitro
TLDR
Serotonin can both depolarize and disinhibit SNr neurons via 5-HT2C and5-HT1B receptors, respectively, but excitation may be limited by GABA released from axon collaterals, while spontaneous tetrodotoxin-sensitive GABAA synaptic currents were increased in frequency but reduced in frequency by serotonin.
...
...