Constitutive high expression of protein arginine methyltransferase 1 in asthmatic airway smooth muscle cells is caused by reduced microRNA-19a expression and leads to enhanced remodeling.

@article{Sun2017ConstitutiveHE,
  title={Constitutive high expression of protein arginine methyltransferase 1 in asthmatic airway smooth muscle cells is caused by reduced microRNA-19a expression and leads to enhanced remodeling.},
  author={Qingzhu Sun and Li Liu and Hui Wang and Jyotshna Mandal and Petra Khan and Katrin E. Hostettler and Daiana Prestes Stolz and Michael Tamm and Antonio Arias-Gago del Molino and Didier Lardinois and Shemin Lu and Michael Roth},
  journal={The Journal of allergy and clinical immunology},
  year={2017},
  volume={140 2},
  pages={
          510-524.e3
        }
}
BACKGROUND In asthma remodeling airway smooth muscle cells (ASMCs) contribute to airway wall thickness through increased proliferation, migration, and extracellular matrix deposition. Previously, we described that protein arginine methyltransferase 1 (PRMT1) participates in airway remodeling in pulmonary inflammation in E3 rats. OBJECTIVE We sought to define the asthma-specific regulatory mechanism of PRMT1 in human ASMCs. METHODS ASMCs from healthy subjects and asthmatic patients were… CONTINUE READING
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