Constitutive heterochromatin formation and transcription in mammals

  title={Constitutive heterochromatin formation and transcription in mammals},
  author={Nehm{\'e} Saksouk and Elisabeth Simboeck and J{\'e}r{\^o}me D{\'e}jardin},
  booktitle={Epigenetics & Chromatin},
Constitutive heterochromatin, mainly formed at the gene-poor regions of pericentromeres, is believed to ensure a condensed and transcriptionally inert chromatin conformation. Pericentromeres consist of repetitive tandem satellite repeats and are crucial chromosomal elements that are responsible for accurate chromosome segregation in mitosis. The repeat sequences are not conserved and can greatly vary between different organisms, suggesting that pericentromeric functions might be controlled… CONTINUE READING
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