Constitutive gene expression and restoration of the normal phenotype in malignant cells: a model for the origin and evolution of leukemia.


The change from normal to malignant cells involves a sequence of changes including specific chromosome changes. After this sequence, some leukemias can still be induced to revert with a high frequency from a malignant to a non-malignant phenotype. Results obtained from the analysis of regulation of growth and differentiation in normal and leukemic myeloid… (More)


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