Constitutive expression of the Wilms' tumor gene WT1 inhibits the differentiation of myeloid progenitor cells but promotes their proliferation in response to granulocyte-colony stimulating factor (G-CSF).

@article{Tsuboi1999ConstitutiveEO,
  title={Constitutive expression of the Wilms' tumor gene WT1 inhibits the differentiation of myeloid progenitor cells but promotes their proliferation in response to granulocyte-colony stimulating factor (G-CSF).},
  author={Akihiro Tsuboi and Y. Oka and Hiroyasu Ogawa and Olga A. Elisseeva and Hiroya Tamaki and Yusuke Oji and E H Kim and Toshihiro Soma and Toyoshi Tatekawa and Manabu Kawakami and Tadamitsu Kishimoto and Haruo Sugiyama},
  journal={Leukemia research},
  year={1999},
  volume={23 5},
  pages={499-505}
}
Bone marrow (BM) cells that were concentrated for hematopoietic progenitor cells by in vivo treatment with 5-FU were infected with a recombinant retrovirus containing a human full-sized, non-spliced type WT1 (Wilms' tumor gene 1) cDNA and then colony-assayed in the presence of granulocyte-colony stimulating factor (G-CSF). Significantly more colony-forming… CONTINUE READING