Constitutive expression of inducible nitric oxide synthase in the mouse ileal mucosa.

@article{Hoffman1997ConstitutiveEO,
  title={Constitutive expression of inducible nitric oxide synthase in the mouse ileal mucosa.},
  author={Rosemary Hoffman and Guobing Zhang and Natascha C. Nuessler and Susan Gleixner and Henri R Ford and Richard L. Simmons and Simon C. Watkins},
  journal={The American journal of physiology},
  year={1997},
  volume={272 2 Pt 1},
  pages={G383-92}
}
It has been demonstrated previously that the inducible isoform of nitric oxide synthase (iNOS) is present throughout the intestinal tract in various inflammatory disease processes. Here we demonstrate that iNOS mRNA is present in the ileum but not in the jejunum or colon of normal mice. By Western blot analysis, iNOS protein is also detected in normal ileum, but not in the normal jejunum. However, by 3 h postinjection of 0.5 mg/kg lipopolysaccharide (LPS), iNOS mRNA is also detectable in the… CONTINUE READING
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