Constitutive expression of Fas (Apo-1/CD95) ligand on multiple myeloma cells: a potential mechanism of tumor-induced suppression of immune surveillance.

@article{Villunger1997ConstitutiveEO,
  title={Constitutive expression of Fas (Apo-1/CD95) ligand on multiple myeloma cells: a potential mechanism of tumor-induced suppression of immune surveillance.},
  author={Andreas Villunger and Alexander Egle and Ingrid Marschitz and Marion Kos and Guenther Boeck and Heinz Ludwig and Stephan Geley and Reinhard Kofler and Richard Greil},
  journal={Blood},
  year={1997},
  volume={90 1},
  pages={
          12-20
        }
}
The Fas (Apo-1/CD95) ligand (FasL) plays a central role in the elimination of target cells by effector T lymphocytes and in the suppression of cellular immune responses against nonmalignant and malignant cells. We show the expression of FasL on the surface of neoplastic plasma cells. We provide evidence that the FasL is functionally active because five of five neoplastic plasma cell lines tested killed CEM-C7H2 T-acute lymphoblastic leukemia (T-ALL) cells. The effect was mediated via the Fas… CONTINUE READING

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