Constitutive expression of Bc1-3 in thymocytes increases the DNA binding of NF-kappaB1 (p50) homodimers in vivo.

@article{Caamao1996ConstitutiveEO,
  title={Constitutive expression of Bc1-3 in thymocytes increases the DNA binding of NF-kappaB1 (p50) homodimers in vivo.},
  author={Jorge H Caama{\~n}o and Paloma P{\'e}rez and Sergio A Lira and R. Lopez Bravo},
  journal={Molecular and cellular biology},
  year={1996},
  volume={16 4},
  pages={1342-8}
}
Previous studies have indicated that Bcl-3 interacts through its ankyrin repeats with the transcriptional factors NF-kappaB1 (p50) and NF-kappaB2 (p52), affecting their biological activities. To further investigate the role of Bcl-3 in vivo and its association with the NF-kappaB proteins, we have generated transgenic mice constitutively expressing Bcl-3 in thymocytes. The results indicate that Bcl-3 is associated with endogenous p50 and p52 in nuclear extracts from transgenic animals… CONTINUE READING

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