Constitutive expression and role of the TNF family ligands in apoptotic killing of tumor cells by human NK cells.

@article{Kashii1999ConstitutiveEA,
  title={Constitutive expression and role of the TNF family ligands in apoptotic killing of tumor cells by human NK cells.},
  author={Yoshiro Kashii and Roberto Giorda and Ronald B. Herberman and Theresa L Whiteside and Nikola L. Vujanovic},
  journal={Journal of immunology},
  year={1999},
  volume={163 10},
  pages={5358-66}
}
Natural killer cells mediate spontaneously secretory/necrotic killing against rare leukemia cell lines and a nonsecretory/apoptotic killing against a large variety of tumor cell lines. The molecules involved in nonsecretory/apoptotic killing are largely undefined. In the present study, freshly isolated, nonactivated, human NK cells were shown to express TNF, lymphotoxin (LT)-alpha, LT-beta, Fas ligand (L), CD27L, CD30L, OX40L, 4-1BBL, and TNF-related apoptosis-inducing ligand (TRAIL), but not… CONTINUE READING

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