Constitutive endocytosis and recycling of NKCC2 in rat thick ascending limbs.

@article{Ares2010ConstitutiveEA,
  title={Constitutive endocytosis and recycling of NKCC2 in rat thick ascending limbs.},
  author={Gustavo Rosier Ares and Pablo Alfredo Ortiz},
  journal={American journal of physiology. Renal physiology},
  year={2010},
  volume={299 5},
  pages={F1193-202}
}
The Na-K-2Cl cotransporter (NKCC2) mediates NaCl absorption by the thick ascending limb of Henle's loop (THAL). Exocytosis and endocytosis regulates surface expression of most transporters. However, little is known about the mechanism of NKCC2 trafficking in the absence of stimulating hormones and whether this mechanism contributes to regulation of steady-state surface expression of apical NKCC2 in the THAL. We tested whether NKCC2 undergoes constitutive endocytosis that regulates steady-state… CONTINUE READING

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