Constitutive dynein activity in she1 mutants reveals differences in microtubule attachment at the yeast spindle pole body

@inproceedings{Bergman2012ConstitutiveDA,
  title={Constitutive dynein activity in she1 mutants reveals differences in microtubule attachment at the yeast spindle pole body},
  author={Zane J. Bergman and Xue Xia and I Alexandra Amaro and Tim C. Huffaker},
  booktitle={Molecular biology of the cell},
  year={2012}
}
The organization of microtubules is determined in most cells by a microtubule-organizing center, which nucleates microtubule assembly and anchors their minus ends. In Saccharomyces cerevisiae cells lacking She1, cytoplasmic microtubules detach from the spindle pole body at high rates. Increased rates of detachment depend on dynein activity, supporting previous evidence that She1 inhibits dynein. Detachment rates are higher in G1 than in metaphase cells, and we show that this is primarily due to… CONTINUE READING

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