Constitutive crosspresentation of tissue antigens by dendritic cells controls CD8+ T cell tolerance in vivo.

@article{Luckashenak2008ConstitutiveCO,
  title={Constitutive crosspresentation of tissue antigens by dendritic cells controls CD8+ T cell tolerance in vivo.},
  author={Nancy Luckashenak and Samira Schroeder and Katrin Endt and Darja Schmidt and Karsten Mahnke and M F Bachmann and Peggy Marconi and Cornelia A Deeg and Thomas Brocker},
  journal={Immunity},
  year={2008},
  volume={28 4},
  pages={521-32}
}
Immature dendritic cells (DCs) sample tissue-specific antigens (TSAs) and process them for "crosspresentation" via major histocompatibility complex (MHC) class I and II molecules. Findings with adoptively transferred T cell receptor (TCR)-transgenic CD8+ T cells in transgenic mice expressing model TSA indicate that this process contributes to tolerance induction of CD8+ T cells, a phenomenon termed "crosstolerance." However, up to now it has been unknown whether "crosstolerance" can also… CONTINUE READING

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