Constitutive c-ets2 expression in M1D+ myeloblast leukemic cells induces their differentiation to macrophages.

@article{Aperlo1996ConstitutiveCE,
  title={Constitutive c-ets2 expression in M1D+ myeloblast leukemic cells induces their differentiation to macrophages.},
  author={Christel Aperlo and Philippe Pognonec and E Richard Stanley and Kim E. Boulukos},
  journal={Molecular and cellular biology},
  year={1996},
  volume={16 12},
  pages={6851-8}
}
The expression of c-ets2 is rapidly induced in a variety of myelomonocytic cell lines as they differentiate into macrophages. We find that constitutive expression of c-ets2 in the M1D+ myeloblast leukemic cell line (M1ets2) is sufficient to push these cells to a more differentiated state. The expression of several differentiation-specific genes is upregulated in M1ets2 cells, including those encoding macrophage-specific lysozyme M and tumor necrosis factor alpha, which are involved in… CONTINUE READING