Constitutive association of SHP-1 with leukocyte-associated Ig-like receptor-1 in human T cells.

@article{Sathish2001ConstitutiveAO,
  title={Constitutive association of SHP-1 with leukocyte-associated Ig-like receptor-1 in human T cells.},
  author={Jean G. Sathish and Kenneth G. Johnson and Kerensa J. Fuller and Frances G Leroy and Linde Meyaard and M. J. Sims and Robt. Matthews},
  journal={Journal of immunology},
  year={2001},
  volume={166 3},
  pages={1763-70}
}
The intracellular Src homology 2 (SH2) domain-containing protein tyrosine phosphatase (SHP-1) is a negative regulator of cell signaling and contributes to the establishment of TCR signaling thresholds in both developing and mature T lymphocytes. Although there is much functional data implicating SHP-1 as a regulator of TCR signaling, the molecular basis for SHP-1 activation in T lymphocytes is poorly defined. A modification of the yeast two-hybrid system was employed to identify in T cells… CONTINUE READING

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