Constitutive androstane receptor-mediated up-regulation of ATP-driven xenobiotic efflux transporters at the blood-brain barrier.

@article{Wang2010ConstitutiveAR,
  title={Constitutive androstane receptor-mediated up-regulation of ATP-driven xenobiotic efflux transporters at the blood-brain barrier.},
  author={Xueqian Wang and Destiny B Sykes and David Scott Miller},
  journal={Molecular pharmacology},
  year={2010},
  volume={78 3},
  pages={376-83}
}
ATP-driven efflux transporters at the blood-brain barrier both protect against neurotoxicants and limit drug delivery to the brain. In other barrier and excretory tissues, efflux transporter expression is regulated by certain ligand-activated nuclear receptors. Here we identified constitutive androstane receptor (CAR) as a positive regulator of P… CONTINUE READING