Constitutive and stimulus-induced phosphorylation of CD11/CD18 leukocyte adhesion molecules

@article{Chatila1989ConstitutiveAS,
  title={Constitutive and stimulus-induced phosphorylation of CD11/CD18 leukocyte adhesion molecules},
  author={Talal A Chatila and Raif S Geha and M. Amin Arnaout},
  journal={The Journal of Cell Biology},
  year={1989},
  volume={109},
  pages={3435 - 3444}
}
The leukocyte CD11/CD18 adhesion molecules (beta 2 integrins) are a family of three heterodimeric glycoproteins each with a distinct alpha subunit (CD11a, b, or c) and a common beta subunit (CD18). CD11/CD18 mediate crucial leukocyte adhesion functions such as chemotaxis, phagocytosis, adhesion to endothelium, aggregation, and cell-mediated cytotoxicity. The enhanced cell adhesion observed upon activation of leukocytes is associated with increased surface membrane expression of CD11/CD18, as… CONTINUE READING

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Mentioned Connections BETA
CD11/CD18 mediate crucial leukocyte adhesion functions such as chemotaxis , phagocytosis , adhesion to endothelium , aggregation , and cell - mediated cytotoxicity .
FMLP - induced phosphorylation of CD18 was not related to its Ca++-mobilizing effect , as CD18 phosphorylation was not observed upon treatment of leukocytes with the Ca++ ionophore , ionomycin .
FMLP - induced phosphorylation of CD18 was not related to its Ca++-mobilizing effect , as CD18 phosphorylation was not observed upon treatment of leukocytes with the Ca++ ionophore , ionomycin .
FMLP - induced phosphorylation of CD18 was not related to its Ca++-mobilizing effect , as CD18 phosphorylation was not observed upon treatment of leukocytes with the Ca++ ionophore , ionomycin .
FMLP - induced phosphorylation of CD18 was not related to its Ca++-mobilizing effect , as CD18 phosphorylation was not observed upon treatment of leukocytes with the Ca++ ionophore , ionomycin .
FMLP - induced phosphorylation of CD18 was not related to its Ca++-mobilizing effect , as CD18 phosphorylation was not observed upon treatment of leukocytes with the Ca++ ionophore , ionomycin .
FMLP - induced phosphorylation of CD18 was not related to its Ca++-mobilizing effect , as CD18 phosphorylation was not observed upon treatment of leukocytes with the Ca++ ionophore , ionomycin .
To elucidate the nature of the qualitative modifications that occur , we examined the phosphorylation status of these molecules in resting human leukocytes and upon activation with PMA or with the chemotactic peptide F - met - leu - phe ( FMLP ) .
To elucidate the nature of the qualitative modifications that occur , we examined the phosphorylation status of these molecules in resting human leukocytes and upon activation with PMA or with the chemotactic peptide F - met - leu - phe ( FMLP ) .
CD11/CD18 mediate crucial leukocyte adhesion functions such as chemotaxis , phagocytosis , adhesion to endothelium , aggregation , and cell - mediated cytotoxicity .
CD11/CD18 mediate crucial leukocyte adhesion functions such as chemotaxis , phagocytosis , adhesion to endothelium , aggregation , and cell - mediated cytotoxicity .
CD11/CD18 mediate crucial leukocyte adhesion functions such as chemotaxis , phagocytosis , adhesion to endothelium , aggregation , and cell - mediated cytotoxicity .
Phosphoamino acid analysis of CD11/CD18 in PMA- or FMLP - treated monocytes revealed a predominance of phosphoserine residues in all CD11/CD18 subunits .
Phosphoamino acid analysis of CD11/CD18 in PMA- or FMLP - treated monocytes revealed a predominance of phosphoserine residues in all CD11/CD18 subunits .
Phosphoamino acid analysis of CD11/CD18 in PMA- or FMLP - treated monocytes revealed a predominance of phosphoserine residues in all CD11/CD18 subunits .
Phosphoamino acid analysis of CD11/CD18 in PMA- or FMLP - treated monocytes revealed a predominance of phosphoserine residues in all CD11/CD18 subunits .
A small component of phosphothreonine was present in CD11c and CD18 and a minor component of phosphotyrosine was also detected in CD18 upon leukocyte activation may regulate the adhesion functions mediated by the CD11/CD18 family of molecules .
A small component of phosphothreonine was present in CD11c and CD18 and a minor component of phosphotyrosine was also detected in CD18 upon leukocyte activation may regulate the adhesion functions mediated by the CD11/CD18 family of molecules .
A small component of phosphothreonine was present in CD11c and CD18 and a minor component of phosphotyrosine was also detected in CD18 upon leukocyte activation may regulate the adhesion functions mediated by the CD11/CD18 family of molecules .
A small component of phosphothreonine was present in CD11c and CD18 and a minor component of phosphotyrosine was also detected in CD18 upon leukocyte activation may regulate the adhesion functions mediated by the CD11/CD18 family of molecules .
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