Constitutive and inducible nitric oxide synthase activities after spinal cord contusion in rats.

@article{DazRuz2002ConstitutiveAI,
  title={Constitutive and inducible nitric oxide synthase activities after spinal cord contusion in rats.},
  author={Araceli D{\'i}az-Ru{\'i}z and Antonio Ibarra and Francisca P{\'e}rez-Severiano and Gabriel Gu{\'i}zar-Sahag{\'u}n and Israel Grijalva and Camilo R{\'i}os},
  journal={Neuroscience letters},
  year={2002},
  volume={319 3},
  pages={129-32}
}
Nitric oxide (NO) plays a role in the secondary damage after spinal cord (SC) injury. NO is produced by the activity of two classes of enzymes: calcium-dependent constitutive nitric oxide synthase (NOS) and calcium-independent inducible NOS. To determine the time course of both NOS activities after SC injury, 50 Wistar rats were submitted to severe SC contusion. NOS activities were assayed at the site of SC injury at several times after lesion. Results showed a significant increase of 138 and… CONTINUE READING

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