Constitutive and inducible expression of hepatic CYP2E1 in leptin-deficient ob/ob mice.

@article{Leclercq2000ConstitutiveAI,
  title={Constitutive and inducible expression of hepatic CYP2E1 in leptin-deficient ob/ob mice.},
  author={Isabelle A. Leclercq and Jacqueline Field and ALD. Enriquez and Geoffrey C. Farrell and Graham R. Robertson},
  journal={Biochemical and biophysical research communications},
  year={2000},
  volume={268 2},
  pages={337-44}
}
In this study we have analyzed the inducible as well as constitutive hepatic expression of Cyp2e1 in a genetic model of obesity and non-insulin dependent (type II) diabetes, the leptin-deficient ob/ob mouse. In obese mice, Cyp2e1 levels were decreased compared to lean littermates. Treatment with leptin increased hepatic Cyp2e1 in obese mice to the levels observed in lean animals, but failed to alter Cyp2e1 expression in lean animals. As expected, leptin also reduced food intake in treated mice… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
21 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 21 extracted citations

Similar Papers

Loading similar papers…