Constitutive and LPS-regulated expression of interleukin-18 receptor beta variants in the mouse brain.

@article{Alboni2011ConstitutiveAL,
  title={Constitutive and LPS-regulated expression of interleukin-18 receptor beta variants in the mouse brain.},
  author={Silvia Alboni and Claudia Montanari and Cristina Benatti and Johanna M.C. Blom and Maria Luisa Simone and Nicoletta Brunello and Federica Caggia and Gianluigi Guidotti and Maria Cecilia Garibaldi Marcondes and Manuel S{\'a}nchez-Alavez and Bruno Conti and Fabio Tascedda},
  journal={Brain, behavior, and immunity},
  year={2011},
  volume={25 3},
  pages={483-93}
}
Interleukin (IL)-18 is a pro-inflammatory cytokine that is proposed to be involved in physiological as well as pathological conditions in the adult brain. IL-18 acts through a heterodimer receptor comprised of a subunit alpha (IL-18Rα) required for binding, and a subunit beta (IL-18Rβ) necessary for activation of signal transduction. We recently demonstrated that the canonical alpha binding chain, and its putative decoy isoform, are expressed in the mouse central nervous system (CNS) suggesting… CONTINUE READING